1. Introduction to Collagen

Collagen is one of the most abundant proteins in the human body and an essential component for tissue elasticity and firmness. Its applications range from cosmetics (anti-aging creams, beauty supplements) to the pharmaceutical sector (tissue regeneration, implants) and the food industry (functional additives). The market is experiencing accelerated growth, driven by consumer preference for products that promote health and aesthetics naturally.

2. Production Process

This project focuses on the production of biomass with high collagen content using fermentation with the yeast Pichia pastoris. This microorganism stands out for its efficiency in synthesizing structural proteins due to its ability to grow at high cell densities and perform post-translational modifications that ensure collagen quality.

The process integrates:

• Cultivation in scalable bioreactors.
• Optimization of parameters (pH, temperature, nutrients) to maximize collagen expression.
• Purification and drying protocols ensuring quality and traceability.

3. Development Plan

• Phase I (R&D): Validation of Pichia pastoris strains, pilot bioreactor trials, and evaluation of cultivation parameters.
• Phase II (Pilot Scaling and Certification Implementation): Adjustment of production capacity, adoption of international standards (GMP, ISO), and acquisition of relevant health certifications.
• Phase III (Industrial Production and Expansion): Consolidation of production capacity, formalization of partnerships with international distributors, and brand positioning in global markets.